ω-Conotoxin MVIIC / Omega conotoxin MVIIC (ω-漏斗網蛛毒素MVIIC)  

Blocker of P/Q and N-type Ca²⁺ channels

P/Q型鈣通道和N型鈣通道阻斷劑

ω-conotoxin MVIIC (omega conotoxin MVIIC) has been isolated from the venom of the cone Conus magus. ω-conotoxin MVIIC is a blocker of P/Q and N-type calcium channels. It inhibits presynaptic Ca²⁺ channels, including the Ca²⁺ channels responsible for Ca²⁺ uptake by rat brain synaptosomes, the P-type Ca²⁺ channels in cerebellar Purkinje cells, and a significant fraction of  ω-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. ω-conotoxin MVIIC also presents an inhibition of  ω-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats. 

ω-conotoxin MVIIC (ω-漏斗網蛛毒素MVIIC)  技術資料

氨基酸序列：

 Cys¹-Lys-Gly-Lys-Gly-Ala-Pro-Cys⁸-Arg-Lys-Thr-Met-Tyr-Asp-Cys¹⁵-Cys¹⁶-Ser-Gly-Ser-Cys²⁰-Gly-Arg-Arg-Gly-Lys-Cys²⁶-NH₂ 
二硫鍵：Cys¹-Cys¹⁶, Cys⁸-Cys²⁰ and Cys¹⁵-Cys²⁶ 
長度 (aa)：26
分子式：C₁₀₆H₁₇₈N₄₀O₃₂S₇ 
分子量：2750.20 Da
外觀：White lyophilized solid
可溶性：water and saline buffer
CAS 號：[147794-23-8]
來源： Synthetic 
純度： > 97 %

產品信息