A selective inhibitor of bone morphogenetic protein （BMP） type I receptors （ALK-2 and ALK-3）. Only weakly inhibits ALK-4,-5, and -7.
4-[6-（4-Piperazin-1-yl-phenyl）-pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline

Ref: Cuny, G.D., et al. Structure-activity relationship study of bone morphogenetic protein （BMP） signaling inhibitors. Bioorg Med Chem Lett 18: 4388-92, 2008.

Catalog #

LDN-02; LDN-10; LDN-50

Description

A selective inhibitor of

bone morphogenetic protein (BMP) type I receptors

(ALK-2 and ALK-3). Only weakly inhibits ALK-4, -5,

and -7.

4-[6-(4-Piperazin-1-yl-phenyl)-pyrazolo[1,5-a]pyrim

idin-3-yl]-quinoline

Ref: Cuny, G.D., et al. Structure-activity relatio

nship study of bone morphogenetic

protein (BMP) signaling inhibitors. Bioorg Med Chem

Lett 18: 4388-92, 2008.

Formulation

Powder

Reconstitution

Before reconstitution, we recommend a brief spin to drive down a

material dislodged from the bottom of the tube. The compound is soluble

in DMSO.

Stability

The powder is stable for at least 2 year if stored at -20

degree C. The

dissolved compound is stable for at least 1 month at 4 degree C, but

should

be stored in aliquots at -20 degree C for longer term. Protect from light.

Purity

Greater than 98% as determined by LC/MS analysis. LC/MS a

nd/or NMR

data available upon request.

Biological Activity

Not determined.

Structural Info

MW:

406.48

Formula:

C25H22N6

Solubility:

Soluble in DMSO at 10 mM.

CAS:

1062368-24-4

For Research Use Only. Not for Use in Humans.

? Purity: Greater than 98% as determined by LC/MS analysis.
? Biological Activity: Not Determined

重慶市華雅干細(xì)胞技術(shù)有限公司

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