6. 黑白箱實(shí)驗(yàn)(light dark box) The subject is placed in the dark portion of the box for a set period of acclimation time. At the end of this period, a door separating the two compartments is opened. The amount of time that the subject takes to emerge fully from the enclosed area into the open area is measured.
7. 社交行為實(shí)驗(yàn)(social interaction) The subject is habituated to the test chamber and allowed to freely explore for a set time. A novel animal is placed in one of the two enclosures, and the percentage of time the mouse spends in the section with the novel animal is compared to the time spent in the section with the empty enclosure. In a later session, the time spent with the same animal might be compared to time spent with a newer, more novel animal.
8. 條件性位置偏愛(Conditioned Place Preference) 條件性位置偏愛實(shí)驗(yàn)(Conditioned Place Preference, CPP)實(shí)驗(yàn)是目前評價(jià)藥物精神依賴性的經(jīng)典實(shí)驗(yàn)?zāi)P停彩菑V泛應(yīng)用于尋找抗覓藥行為的有效工具。該實(shí)驗(yàn)將實(shí)驗(yàn)動(dòng)物(大鼠、小鼠)置于條件性位置偏愛箱的白色觀察區(qū),并給予精神依賴性藥物(例如*),然后觀察實(shí)驗(yàn)動(dòng)物在條件性位置偏愛箱的黑色區(qū)和白色區(qū)的活動(dòng)情況,白色區(qū)、黑色區(qū)以及其中的灰色 區(qū)之間有小門可供動(dòng)物自由穿梭。動(dòng)物每次處于給藥區(qū)就會(huì)在藥物獎(jiǎng)賞性效應(yīng)的作用下對黑色和白色區(qū)域產(chǎn)生位置上的偏好,其程度與藥物的精神依賴性相關(guān)。 9. 懸尾 懸尾實(shí)驗(yàn)主要用于抗抑郁、鎮(zhèn)靜以及止痛類藥物的研究。懸尾實(shí)驗(yàn)系統(tǒng)適用于大鼠、小鼠或其他實(shí)驗(yàn)室動(dòng)物,通過固定動(dòng)物尾部使其頭向下懸掛,記錄處于該環(huán)境的動(dòng)物產(chǎn)生絕望的不動(dòng)狀態(tài)過程中的一系列參數(shù)。 10. 條件性恐懼實(shí)驗(yàn)(fear conditioning) 條件性恐懼分析用于小型嚙齒類動(dòng)物(大、小鼠)環(huán)境相關(guān)條件性恐懼實(shí)驗(yàn)研究。抗抑郁藥和抗中樞興奮藥可以明顯縮短不動(dòng)狀態(tài)持續(xù)的時(shí)間。實(shí)驗(yàn)過程中,實(shí)驗(yàn)對象被給與一個(gè)聲音信號,隨后給予電擊刺激。該訓(xùn)練稱為條件性訓(xùn)練,訓(xùn)練結(jié)束后實(shí)驗(yàn)動(dòng)物進(jìn)行聲音信號或環(huán)境性實(shí)驗(yàn)。一般情況下嚙齒類動(dòng)物對相應(yīng)的環(huán)境和不同環(huán)境下同樣的聲音信號都會(huì)做出明顯的條件性恐懼反應(yīng),如靜止不動(dòng)。 11. 震驚條件反射(startle and pre-pulse inhibition)
12.新穎物體識別(novel object recognition) The subject is habituated to the test chamber and allowed to freely explore for a set time. A novel object is placed in one of the two enclosures, and the percentage of time the mouse spends in the section with the new object is compared to the time spent in the section with the empty enclosure. In a later session, the time spent with the same object might be compared to time spent with a newer, more novel object.
|
相關(guān)產(chǎn)品
免責(zé)聲明
- 凡本網(wǎng)注明“來源:化工儀器網(wǎng)”的所有作品,均為浙江興旺寶明通網(wǎng)絡(luò)有限公司-化工儀器網(wǎng)合法擁有版權(quán)或有權(quán)使用的作品,未經(jīng)本網(wǎng)授權(quán)不得轉(zhuǎn)載、摘編或利用其它方式使用上述作品。已經(jīng)本網(wǎng)授權(quán)使用作品的,應(yīng)在授權(quán)范圍內(nèi)使用,并注明“來源:化工儀器網(wǎng)”。違反上述聲明者,本網(wǎng)將追究其相關(guān)法律責(zé)任。
- 本網(wǎng)轉(zhuǎn)載并注明自其他來源(非化工儀器網(wǎng))的作品,目的在于傳遞更多信息,并不代表本網(wǎng)贊同其觀點(diǎn)和對其真實(shí)性負(fù)責(zé),不承擔(dān)此類作品侵權(quán)行為的直接責(zé)任及連帶責(zé)任。其他媒體、網(wǎng)站或個(gè)人從本網(wǎng)轉(zhuǎn)載時(shí),必須保留本網(wǎng)注明的作品第一來源,并自負(fù)版權(quán)等法律責(zé)任。
- 如涉及作品內(nèi)容、版權(quán)等問題,請?jiān)谧髌钒l(fā)表之日起一周內(nèi)與本網(wǎng)聯(lián)系,否則視為放棄相關(guān)權(quán)利。